Water for ADPKD? Probably, Yes

Should every Patient with MDS get Iron Chelation – Probably Yes

Antibiotics as first-line therapy for Hp-associated gastric large B-cell lymphoma? Probably yes.

Sex during pregnancy: Yes, Yes, Yes!

Regular readers of this Journal will recall that it was just over a year ago that I was commissioned to explore the issue of ‘Grey Sex’:1 sexuality in the older age group and the challenges that raises for health professionals, not least in leading us to acknowledge that for human beings the sexual impulse does not inevitably fade. Fast forward, and in this Journal issue I want to explore sex a...

Unified criteria for ultrasonographic diagnosis of ADPKD.

Individuals who are at risk for autosomal dominant polycystic kidney disease are often screened by ultrasound using diagnostic criteria derived from individuals with mutations in PKD1. Families with mutations in PKD2 typically have less severe disease, suggesting a potential need for different diagnostic criteria. In this study, 577 and 371 at-risk individuals from 58 PKD1 and 39 PKD2 families,...

Copeptin: a marker for ADPKD progression?

Autosomal dominant polycystic kidney disease (ADPKD) accounts for ∼5–10% of patients with end-stage renal disease (ESRD) [1]. Mutations in the PKD1 and PKD2 gene, encoding polycystin-1 (PC-1) and -2 (PC-2), account for ∼85 and 15% of diseases, respectively. PC-1 interacts with PC-2 to build a multifunctional signalling complex that regulates intracellular Ca signalling, and epithelial developme...